New Delhi, India – 110 016

Cyramza (Ramucirumab) Injection

Generic brands for Ramucirumab Injection Available in India

Brand Name Cyramza
Generic Name Ramucirumab
Strength 100mg 500mg
Manufacturer Eli Lilly And Company Ind

 

Description

Description

This page contains brief details about the drug ramucirumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Ramucirumab is an anticancer medication containing the active ingredient Ramucirumab. It is a monoclonal antibody drug. Cancer is a condition in which cells multiply uncontrolled and abnormally. This medication treats advanced stomach, colon, rectum, lungs, and liver cancers. It may be given alone or in combination with other anticancer medications to treat various types of cancer. The benefits of Ramucirumab are that it can help to slow down the growth and spread of cancer cells in various types of cancer. Studies have shown that this medication can improve survival rates and increase the time until cancer progresses to the advanced stage.

Ramucirumab was approved by the United States Food and Drug Administration (FDA) in April 2014 for the treatment of advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma, as well as for the treatment of metastatic non-small cell lung cancer (NSCLC) in combination with other anticancer drug.

Mechanism of Action of Ramucirumab

It works by targeting and inhibiting the action of a protein called vascular endothelial growth factor receptor 2 (VEGFR2), which plays a key role in the growth and development of blood vessels that feed tumors. By blocking VEGFR2, ramucirumab helps to prevent the growth and spread of cancer cells.

Uses of Ramucirumab

Ramucirumab is used to treat several types of cancer, including advanced gastric cancer or gastroesophageal junction adenocarcinoma, non-small cell lung cancer, hepatocellular carcinoma, and colorectal cancer.

Ramucirumab Dosage available

A healthcare professional administers Ramucirumab through intravenous injection in a hospital or clinic setting. It is not intended for self-administration. The recommended dosage and frequency depends on the type and stage of the cancer being treated, the individual patient’s medical history, and overall health status. The drug is usually administered with chemotherapy or as a standalone treatment.

If you miss a scheduled dose, contact your healthcare provider as soon as possible to discuss the best course of action. Sometimes, your healthcare provider may recommend that you receive the missed dose as soon as possible and then resume the regular dosing schedule. However, this will depend on several factors, such as how long it has been since your last dose, overall health status, and cancer stage. It is important not to double the dose to make up for a missed dose, as this can increase the risk of side effects.

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News/Updates

References

  1. Genzyme Corporation, U.S. Food & Drug Administration [Revised on Dec 2017] [Accessed on 13th Apr 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022311s018lbl.pdf
  2. Seacross Pharmaceuticals Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 20th April 2023],  Plerixafor Seacross 20 mg/ml solution for injection – Patient Information Leaflet (PIL) – (emc) (medicines.org.uk)
  3. James L. Zehnder, Agents Used in Cytopenias; Hematopoietic Growth Factors, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 591- 607.
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