Description
Description
This page contains brief details about the drug bevacizumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Bevacizumab is the first antiangiogenic agent (a drug that blocks the formation of blood vessels) which was approved for its medical use in 2004.
Mechanism of Action of Bevacizumab
Bevacizumab Injection is a biological agent that acts as targeted drug therapy in cancer treatment. It is classified as a monoclonal antibody belonging to the class VEGF inhibitors. VEGF -A is a factor involved in the formation of blood vessels within the tumor that feed the tumors with adequate nutrition and oxygen for the tumor growth. Thus, bevacizumab selectively binds to the tumor and prevents its growth. It is often administered in combination with other chemotherapy agents.
Uses of Bevacizumab
Bevacizumab Injection has been developed to treat solid tumors by injecting it directly into the bloodstream. Bevacizumab Injection has been approved to treat several primary and advanced-stage cancers such as metastatic breast cancer, metastatic cervical cancer, Glioblastoma multiforme (brain cancer), advanced kidney cancer, metastatic colorectal cancer, advanced non-small-cell lung cancer, Liver Cancer- Hepatocellular carcinoma and the cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer.
Bevacizumab Dosage available
A healthcare professional will administer Bevacizumab injection as an intravenous infusion to the patients. The first dose will be given for 90 minutes and later the duration of the infusion will be reduced to 30 minutes if the patient is well tolerated. The number of infusions to be administered is typically based on the patient’s response to the therapy.
The oncologist will calculate the amount of Bevacizumab Injection administered based on the patients’ height, weight, body surface area, and the type of cancer being diagnosed. This injection is available in two dosages i.e bevacizumab 100mg injection and 400mg injection. Each 4ml vial contains 100mg of Bevacizumab Injection and a 16ml vial contains 400mg of Bevacizumab Injection.
