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Amphonat (Liposomal Amphotericin B) Injection

Generic brands for Liposomal Amphotericin B Injection  Available in India

Generic brands for Liposomal Amphotericin B Injection  Available in India

Brand Name Amphonat
Generic Name Liposomal Amphotericin B
Strength 50mg
Manufacturer Natco Pharma Ltd

Description

Description

This page contains brief details about the drug liposomal amphotericin b, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Liposomal Amphotericin B is an antifungal antibiotic. FDA approved this medicine on 11th August 1997 for its medical use.

Mechanism of Action of Liposomal Amphotericin B

Liposomal Amphotericin B binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.

Uses of Liposomal Amphotericin B

It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.

Liposomal Amphotericin B Dosage available

A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

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References

  1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Chemotherapy of protozoal infections, 12th edition, 2011, 1424.
  2. KD Tripathi, Essentials of Medical Pharmacology, Antifungal drugs, 7th edition, 2013, 787-788.
  3. Gilead Sciences International Ltd, Electronic medicines compendium (emc), [ Revised on Sept 2020] [ Accessed on 11th June 2023], https://www.medicines.org.uk/emc/files/pil.1022.pdf
  4. Gilead Sciences, Inc, US Food and Drug Administration, [ Revised on Oct 2008] [ Accessed on 11th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050740s016lbl.pdf
  5. Lifecare innovations; Accessed on June 12th 2023; https://www.lifecareinnovations.com/mucormycosis.php
  6. Falah Hasan et al; Topical Amphotericin B formulas: Promising new application; Published on August 2019; Accessed on June 12th 2023; https://www.researchgate.net/publication/334882993_Topical_Amphotericin_B_formulas_Promising_new_application
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