New Delhi, India – 110 016

Acabrunat (Acalabrutinib) Capsule available Delhi, Mumbai, Madras, Hyderabad, Bangalore India

Acabrunat (Acalabrutinib) Capsule

Generic brands for Acalabrutinib Capsule Available in India

Brand Name Acabrunat
Generic Name Acalabrutinib
Strength 100mg
Manufacturer Natco Pharma Ltd

 

Description

Description

This page contains brief details about the drug acalabrutinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Acalabrutinib is an anticancer medicine containing the active constituent acalabrutinib. It belongs to a class of drugs called Bruton’s tyrosine kinase (BTK) inhibitors. Acalabrutinib was first approved by the U.S. Food and Drug Administration (FDA) on October 31, 2017, to treat adult patients with mantle cell lymphoma who have received at least one prior therapy. It was later approved by the FDA on August 17, 2020, for the treatment of adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

Mechanism of Action of Acalabrutinib

The mechanism of acalabrutinib, inhibits the activity of Bruton’s tyrosine kinase (BTK). This protein is essential for the survival and growth of cancer cells in certain types of lymphomas and leukemias. By blocking BTK, it can help to slow down or even stop the growth and spread of cancer cells, which can lead to a reduction in tumor size, an improvement in symptoms, and a delay in disease progression.

Uses of Acalabrutinib

Acalabrutinib is used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma (SLL). MCL, CLL, and SLL are cancers of the white blood cells called lymphocytes that are part of the immune system.

Acalabrutinib Dosage available

Acalabrutinib is typically administered through injection by a healthcare provider. The specific method of administration may vary depending on the condition being treated and the healthcare provider’s instructions. If a dose is missed, the patient should contact their healthcare provider for further instructions.

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References

  1. AstraZeneca, Electronica medicines compendium (EMC), [Revised on Dec 2020], [ Accessed on 5th May 2023],  https://www.medicines.org.uk/emc/files/pil.11917.pdf
  2. AstraZeneca, US Food and Drug Administration, [ Revised on Oct 2017], [ Accessed on 5th May 2023],  https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf
  3. John C Byrd et al; Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results; Blood; Published on April 2020; [Accessed on5th May 2023];  https://pubmed.ncbi.nlm.nih.gov/31876911/
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Frequently Asked Questions

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Medicines once shipped will not be taken back. We will assist you with the Export Invoice and tracking details of your order. International orders might be subject to import taxes/duties. For information, please contact your local customs authority. Any such taxes are the responsibility of the parcel recipient and are not paid by us.

There are some medicines which have been approved recently in USA or Europe but not yet approved in India or any other countries are not permitted to be imported or marketed commercially. However, they may be required for the treatment of patients to save their lives who have exhausted all other available treatment options in their country. Named – Patient Program is to facilitate import of such medicines for personal use. There is a provision under the Indian Drugs and Cosmetics Rules, 1945, that permits the patient to import these medicine in small quantity. Similar regulatory provision also exist in other countries. We assist patient in preparing legal documents for import and connecting them with authorized suppliers in USA and Europe to secure genuine products.

A generic drug is a drug defined as “a drug product that is comparable to a brand/reference listed drug product in dosage form, strength, quality and performance characteristics, and intended use”. There are Indian companies which manufacture and market these generic medicines after getting approval from Regulatory Authority of the country. These generic medicines contain the same active ingredients as the original formulation and are identical or within an acceptable bioequivalent range to the Innovator drug counterpart with respect to pharmacokinetic and pharmaco-dynamic properties. By extension, therefore, generics are considered identical in dose, strength, route of administration, safety, efficacy, and intended use. They are labeled with the name of the manufacturer and the adopted name (nonproprietary name) of the drug. When generic products become available, the market competition often leads to substantially lower prices and thereby make is affordable for large number of needy patients.

It usually takes 8-9 working days after dispatch to reach medicine at outside India locations. Additional delays may occur due to heavy load on postal services and customs.

We advise to transfer money only through Interbank Transfer Modalities;

  • Online Net-banking for within India transfer.
  • International Wire Transfer (SWIFT) from outside India.
  • Cash on Delivery within India.

Cash on Delivery (COD) option is only available if the medicine is purchased and delivered in India. Preferred locations within India for COD facilities are within Municipal limits of New Delhi & NCR, Mumbai, Bangalore, Kolkata, Chennai & Hyderabad

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