New Delhi, India – 110 016

Abakast L (Abacavir+Lamivudine) Tablet

Generic brands for Netupitant+Palonosetron Injection  Available in India

Brand Name Abakast L
Generic Name Abacavir+Lamivudine
Strength
Manufacturer Aprazer Healthcare Pvt Ltd

Description

Description

This page contains brief details about the drug abacavir,lamivudine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Abacavir and Lamivudine are antiretroviral medications containing the active constituents Abacavir and Lamivudine. Both medications belong to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs) and are often used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) or combination antiretroviral therapy (cART). It is used to treat HIV-1 infection. HIV-1 is a virus known as the Human immunodeficiency virus, which targets and eradicates immune system cells, ultimately weakening the body’s defense against infections. If left untreated, it can result in death. While this medication does not offer a complete cure, it effectively lowers the virus levels in your body and boosts the count of CD4 cells in your bloodstream. These cells play a crucial role in assisting your body’s fight against infections. The initial FDA approval date for abacavir was December 17, 1998; lamivudine was November 17, 1995.

Mechanism of Action of Abacavir+Lamivudine

Abacavir and lamivudine work by inhibiting the reverse transcriptase enzyme, which is necessary for the replication of HIV. By blocking this enzyme, the drugs help reduce the viral load in the body, slow the progression of HIV infection, and improve the immune system’s function.

Uses of Abacavir+Lamivudine

Abacavir and Lamivudine are used in the treatment of HIV-1 infection.

Abacavir+Lamivudine Dosage available

To use Abacavir and Lamivudine, follow your healthcare provider’s prescribed dosage and instructions. Take the medications as directed, usually orally, with or without food. Do not skip doses or stop taking them without consulting your healthcare provider. Consult your healthcare provider or pharmacist for guidance if you have any questions or concerns.

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References

  1. KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 807-808.
  2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1635-1636.
  3. Lupin Healthcare (UK) Limited, Electronic medicines compendium (EMC), [ Revised on April 2023] [ Accessed on 27th May 2023], https://www.medicines.org.uk/emc/landing/status=1
  4. ViiV Healthcare, US Food, and Drug Administration, [ Revised on May 2019] [ Accessed on 27th May June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/090519PI.pdf
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