New Delhi, India – 110 016

Lorbriqua (Lorlatinib) Tablet

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Generic brands for Lomustine Capsule Available in India

Brand Name Lomoother
Generic Name Lomustine
Strength 40mg
Manufacturer Therdose Pharma Pvt Ltd

Original price was: ₹51,000.00.Current price is: ₹40,800.00.

Description

Description

This page contains brief details about the drug lorlatinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

LORBRIQUA 100MG  (15TAB) 3 X 5TAB 120000 156000
LORBRIQUA 25MG (15 TAB) 3 X 5TAB 40800 51000

Date of Approval

Lorlatinib is a targeted cancer medication that was approved for its medical use on 2nd November 2018.

Mechanism of Action of Lorlatinib

Lorlatinib Tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is classified as a kinase inhibitor and comes under the class of ALK and ROS-1 inhibitor. Anaplastic Lymphoma Kinase and ROS proto-oncogene are the two genes that promote cellular proliferation and tumour growth in non-small cell lung cancer by undergoing mutation. It works by inhibiting the cell signaling of these genes, ultimately inhibiting tumour growth.

Uses of Lorlatinib

Lorlatinib Tablet has been developed to treat adults with Non-small cell lung cancer (NSCLC) that resulted due to mutation in Anaplastic Lymphoma Kinase and ROS-1 genes and has spread to other parts of the body.

Lorlatinib Dosage available

Your doctor will decide the dose and duration of Lorlatinib based on the disease condition and other factors. Take the tablet at the same time everyday, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

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News/Updates

References

  1. Pfizer Ltd, [Revised on Mar 2021] [Accessed on 1st April 2023], https://labeling.pfizer.com/ShowLabeling.aspx?id=11140&Section=PPI
  2. Pfizer Ltd, Electronic medicines compendium (emc), [Revised on March 2021] [Accessed on 1st April 2023], https://www.medicines.org.uk/emc/files/pil.10632.pdf
  3. Pfizer, US Food and Drug Administration, [Revised on March 2021] [Accessed on 1st April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/210868s004lbl.pdf
  4. Alice T Shaw et al; First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer; The New England Journal of Medicine; Published on 19/11/2020;[Accessed on 1st April 2023]; https://pubmed.ncbi.nlm.nih.gov/33207094/
  5. Haidar El Darsa, Omar Abdel-Rahman & Randeep Sangha (2020) Pharmacological and clinical properties of lorlatinib in the treatment of ALK-rearranged advanced non-small cell lung cancer, Expert Opinion on Pharmacotherapy, 21:13, 1547-1554,[Accessed on 1st April 2023], https://doi.org/10.1080/14656566.2020.1774552
  6. Gafer H, de Waard Q, Compter A, van den Heuvel M. Rapid regression of neurological symptoms in patients with metastasis ALK+ lung cancer who are treated with lorlatinib: a report of two cases. BMJ Case Rep. 2019 Jul 24;12(7):e227299,[Accessed on 1st April 2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663151/pdf/bcr-2018-227299.pdf
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