New Delhi, India – 110 016

Nitsum (Carmustine) Injection available Delhi, Mumbai, Madras, Hyderabad, Bangalore India

Nitsum (Carmustine) Injection

Generic brands for Carmustine Injection Available in India

Brand Name Nitsum
Generic Name Carmustine
Strength 100mg
Manufacturer Celon Laboratories Ltd

 

Description

Description

This page contains brief details about the drug carmustine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Carmustine is an anti-cancer medication that belongs to the class of alkylating agents approved on 25 February 2003 for treating various types of cancer.

Mechanism of Action of Carmustine

Carmustine belongs to a group of anticancer medicines known as nitrosourea alkylating agents that act by slowing the growth of cancer cells and killing them. Carmustine injection is used to treat certain types of brain tumors. Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production, and RNA translation (protein synthesis). This stops cell division and leads to cell death. In addition to other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation (modification) of amino acids in proteins.

Uses of Carmustine

Carmustine has the ability to penetrate the CNS, so they are primarily used in the treatment of brain tumors. It is indicated as palliative therapy as a single agent or combined with other anti-cancer medicines as a secondary therapy for treating various cancers. It is used in brain tumors such as glioblastoma (cancer affecting the brain and spine), brainstem glioma, medulloblastoma (the most common type of brain cancer that affects the cerebellum, a part of the brain), astrocytoma (a type of brain tumor originate from star-shaped brain cells in the cerebrum called astrocytes), ependymoma ( Brain tumor begins in the ependymal cells in the brain and spinal cord), and metastatic brain tumors. Carmustine is also used to treat multiple myeloma in combination with prednisone. It is also used to treat Hodgkin lymphoma and non-Hodgkin lymphoma with other drugs in patients whose disease has not improved with other treatments or has recurred.

Carmustine Dosage available

Carmustine injection comes in a powder form to be added to fluid and as a wafer (implant). The drug will be administered by the healthcare professional. Your physician will decide on the dose and frequency of the injection. Generally, for treating brain tumors, multiple myeloma, hodgkin’s disease, and non-hodgkin’s disease, the dose ranges from 150-200 mg/m² injected intravenously (IV)  as a single dose or divided in two days for every 6 Weeks or 75-100 mg/m²/day intravenously (IV) for 2 days every 6 Weeks. Carmustine must be given slowly, and the infusion can take at least 2 hours to complete. The dose indicated for recurrent glioblastoma is up to 8 wafers placed in the surgical resection cavity of the brain in addition to the surgery. The dose of newly-diagnosed high-grade glioma, in addition to surgery and radiation, is up to 8 wafers placed in the surgical resection cavity of the brain.

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References

  1. BiCNU, Gliadel (carmustine) dosing, indications, interactions, adverse effects, and more. reference.medscape.com. (Accessed December 21, 2022). https://reference.medscape.com/drug/bicnu-gliadel-carmustine-342194#5
  2. Carmustine injection/implant Uses, Side Effects & Warnings. Drugs.com. Accessed December 21, 2022. https://www.drugs.com/mtm/carmustine-injection-implant.html
  3. Micromedex Products: Micromedexsolutions.com. Published 2019. (Accessed 21, December 2022) s://www.micromedexsolutions.com/micromedex2/librarian/PFDefaultActionId/evidencexpert.DoIntegratedSearch?navitem=topHome&isToolPage=true#
  4. Tripathi KD. Essentials of Medical Pharmacology. Jaypee Brothers Medical Publishers; 2019:920-921. Accessed December 21, 2022. file:///C:/Users/BIS/Downloads/Essentials%20of%20Medical%20Pharmacology%20(%20PDFDrive%20).pdf
  5. Chaichana KL, Zaidi H, Pendleton C, McGirt MJ, Grossman R, Weingart JD, Olivi A, Quiñones-Hinojosa A, Brem H. The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival. Neurol Res. 2011 Sep;33(7):759-64. doi: 10.1179/1743132811Y.0000000006. PMID: 21756557; PMCID: PMC4612577 (Accessed December 21, 2022).
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Medicines once shipped will not be taken back. We will assist you with the Export Invoice and tracking details of your order. International orders might be subject to import taxes/duties. For information, please contact your local customs authority. Any such taxes are the responsibility of the parcel recipient and are not paid by us.

There are some medicines which have been approved recently in USA or Europe but not yet approved in India or any other countries are not permitted to be imported or marketed commercially. However, they may be required for the treatment of patients to save their lives who have exhausted all other available treatment options in their country. Named – Patient Program is to facilitate import of such medicines for personal use. There is a provision under the Indian Drugs and Cosmetics Rules, 1945, that permits the patient to import these medicine in small quantity. Similar regulatory provision also exist in other countries. We assist patient in preparing legal documents for import and connecting them with authorized suppliers in USA and Europe to secure genuine products.

A generic drug is a drug defined as “a drug product that is comparable to a brand/reference listed drug product in dosage form, strength, quality and performance characteristics, and intended use”. There are Indian companies which manufacture and market these generic medicines after getting approval from Regulatory Authority of the country. These generic medicines contain the same active ingredients as the original formulation and are identical or within an acceptable bioequivalent range to the Innovator drug counterpart with respect to pharmacokinetic and pharmaco-dynamic properties. By extension, therefore, generics are considered identical in dose, strength, route of administration, safety, efficacy, and intended use. They are labeled with the name of the manufacturer and the adopted name (nonproprietary name) of the drug. When generic products become available, the market competition often leads to substantially lower prices and thereby make is affordable for large number of needy patients.

It usually takes 8-9 working days after dispatch to reach medicine at outside India locations. Additional delays may occur due to heavy load on postal services and customs.

We advise to transfer money only through Interbank Transfer Modalities;

  • Online Net-banking for within India transfer.
  • International Wire Transfer (SWIFT) from outside India.
  • Cash on Delivery within India.

Cash on Delivery (COD) option is only available if the medicine is purchased and delivered in India. Preferred locations within India for COD facilities are within Municipal limits of New Delhi & NCR, Mumbai, Bangalore, Kolkata, Chennai & Hyderabad

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