New Delhi, India – 110 016

Lyoble (Bleomycin) Injection available Delhi, Mumbai, Madras, Hyderabad, Bangalore India

Lyoble (Bleomycin) Injection

Generic brands for Bleomycin Injection Available in India

Brand Name Lyoble
Generic Name Bleomycin
Strength 15IU
Manufacturer United Biotech Pvt Ltd

Description

Description

This page contains brief details about the drug bleomycin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Bleomycin consists of the active ingredient Bleomycin. It belongs to a group of drugs known as antineoplastic antibiotics. It is commonly used in cancer treatment to slow or stop the growth of cancer cells. It treats lymph node cancers (Hodgkin’s and non-Hodgkin’s lymphoma), head and neck cancer, and cancer in external genitalia. It either be used alone or with radiotherapy and chemotherapy treatment. This injection is also beneficial to prevent and treat the fluid accumulation in the lungs due to cancer.

Bleomycin was first approved by the US Food and Drug Administration (FDA) in 1973 for the treatment of several types of cancer, including Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, squamous cell carcinoma, and testicular cancer. It is also used off-label for treating other types of cancers, such as cervical cancer and melanoma. Bleomycin is a glycopeptide antibiotic that was first isolated from a bacteria named Streptomyces verticillus in 1966.

Mechanism of Action of Bleomycin

Bleomycin is inhibiting cancer cell growth and proliferation. By interfering with DNA replication and transcription, it can slow or stop the growth of cancer cells, leading to their destruction. This effect is particularly important in the treatment of Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, testicular cancer, and some types of lung cancer, where rapid cell growth and division are characteristic features of the disease. Overall, it can help to shrink tumors and improve symptoms in cancer patients.

Uses of Bleomycin

Bleomycin is primarily used to treat several types of cancer, including Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, squamous cell carcinoma, and testicular cancer. It is also used off-label for treating other types of cancers, such as cervical cancer and melanoma. As part of a chemotherapy regimen, it is often used with other drugs to increase its effectiveness. In some cases, it may also be used as a single agent for treating certain cancers. It is particularly effective in the treatment of testicular cancer.

Bleomycin Dosage available

Bleomycin is administered through injection by a healthcare provider in a hospital or clinical setting. The dosage and frequency of administration will vary depending on the type of cancer being treated, the patient’s age and weight, and other factors. It should not be taken orally, as it is not absorbed well through the gastrointestinal tract and may cause serious side effects if ingested.

During treatment, patients should follow their healthcare provider’s instructions closely and attend all scheduled appointments to monitor their condition and response to treatment. If a dose is missed, patients should contact their healthcare provider immediately for instructions on when to take the next dose. It is important not to double the dose to make up for a missed one.

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References

  1. Nippon Kayaku Co., Ltd., US Food and Drug Administration, [Revised on April 2010], [Accessed on 1st Apr 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/050443s036lbl.pdf
  2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  3. Accord Healthcare Limited, Electronic Medicines Compendium(EMC), [Revised on Mar 2018] [Accessed on 1st Apr 2023], https://www.medicines.org.uk/emc/files/pil.9333.pdf
  4. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology, 11th edition. Lippincott Williams & Wilkins, 2019, 573-582.
  5. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition, 2017, 1317-1322
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Frequently Asked Questions

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There are some medicines which have been approved recently in USA or Europe but not yet approved in India or any other countries are not permitted to be imported or marketed commercially. However, they may be required for the treatment of patients to save their lives who have exhausted all other available treatment options in their country. Named – Patient Program is to facilitate import of such medicines for personal use. There is a provision under the Indian Drugs and Cosmetics Rules, 1945, that permits the patient to import these medicine in small quantity. Similar regulatory provision also exist in other countries. We assist patient in preparing legal documents for import and connecting them with authorized suppliers in USA and Europe to secure genuine products.

A generic drug is a drug defined as “a drug product that is comparable to a brand/reference listed drug product in dosage form, strength, quality and performance characteristics, and intended use”. There are Indian companies which manufacture and market these generic medicines after getting approval from Regulatory Authority of the country. These generic medicines contain the same active ingredients as the original formulation and are identical or within an acceptable bioequivalent range to the Innovator drug counterpart with respect to pharmacokinetic and pharmaco-dynamic properties. By extension, therefore, generics are considered identical in dose, strength, route of administration, safety, efficacy, and intended use. They are labeled with the name of the manufacturer and the adopted name (nonproprietary name) of the drug. When generic products become available, the market competition often leads to substantially lower prices and thereby make is affordable for large number of needy patients.

It usually takes 8-9 working days after dispatch to reach medicine at outside India locations. Additional delays may occur due to heavy load on postal services and customs.

We advise to transfer money only through Interbank Transfer Modalities;

  • Online Net-banking for within India transfer.
  • International Wire Transfer (SWIFT) from outside India.
  • Cash on Delivery within India.

Cash on Delivery (COD) option is only available if the medicine is purchased and delivered in India. Preferred locations within India for COD facilities are within Municipal limits of New Delhi & NCR, Mumbai, Bangalore, Kolkata, Chennai & Hyderabad

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