New Delhi, India – 110 016

Cytocristin (Vincristine Sulphate) Injection available Delhi, Mumbai, Madras, Hyderabad, Bangalore India

Cytocristin (Vincristine Sulphate) Injection

Generic brands for Vincristine Sulphate Injection Available in India

Brand Name Cytocristin
Generic Name Vincristine Sulphate
Strength 1mg
Manufacturer Cipla Ltd

Description

Description

This page contains brief details about the drug vincristine sulphate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Vincristine sulphate is a chemotherapy medication containing the active constituent vincristine sulphate. It belongs to a class of drugs called vinca alkaloids, which inhibit the growth of cancer cells. This medication treats blood, head, breast, neck, kidney, bone, or lung cancers. It treats rhabdomyosarcoma (cancer that affects muscle tissue) and neuroblastoma (cancer that develops from immature nerve cells). It may also treat multiple myeloma (cancer of plasma cells), thyroid cancer, and a blood disorder known as idiopathic thrombocytopenic purpura (ITP). Cancer is a disorder in which cells multiply uncontrolled and abnormally.

Vincristine sulphate was first approved by the FDA in 1963 for treating acute lymphocytic leukemia (ALL). Since then, it has received additional approvals for treating other types of cancer. Like all chemotherapy drugs, it can cause side effects, such as nausea, vomiting, constipation, hair loss, and fatigue. Patients should discuss the potential benefits and risks of treatment with their doctor.

Mechanism of Action of Vincristine Sulphate

The therapeutic effect of vincristine sulphate inhibits the growth and spread of cancer cells. Vincristine sulphate disrupts the formation and function of microtubules, which are structures inside cells that help with cell division and movement. By interfering with microtubule function, this medication can prevent cancer cells from dividing and multiplying and can also cause them to die.

Uses of Vincristine Sulphate

Vincristine sulphate is used to treat various types of cancer, including blood cancers such as acute lymphocytic leukemia (ALL), head and neck cancers, breast cancer, kidney cancer, bone cancer, and lung cancer. It is also used to treat idiopathic thrombocytopenic purpura (a condition in which the immune system attacks and destroys platelets cells) and multiple myeloma (a type of blood cancer that affects plasma cells). In addition, this medication is used to treat rhabdomyosarcoma (cancer that forms in the body’s soft tissues) and neuroblastoma (cancer that develops in certain nerve cells). It may also be used to treat thyroid cancer.

Vincristine Sulphate Dosage available

A healthcare professional usually administers vincristine sulphate intravenous injection (IV) in a hospital or clinical setting. It should not be taken orally or applied topically to the skin. If you miss a dose, do not double the dose to make up for the missed one.

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References

  1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1707.
  2. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 865.
  3. Hospira UK Ltd, Electronic medicines compendium (EMC), [Revised on March 2022] [ Accessed on 18 April 2023], https://www.medicines.org.uk/emc/files/pil.1501.pdf
  4. Hospira, Inc, US Food and Drug Administration, [Revised on July 2013] [ Accessed on 18th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/071484s042lbl.pdf
  5. Jan Skubnik et al; Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics; Biology; Published on 31/08/2021;  Accessed on 18th April 2023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468923/
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There are some medicines which have been approved recently in USA or Europe but not yet approved in India or any other countries are not permitted to be imported or marketed commercially. However, they may be required for the treatment of patients to save their lives who have exhausted all other available treatment options in their country. Named – Patient Program is to facilitate import of such medicines for personal use. There is a provision under the Indian Drugs and Cosmetics Rules, 1945, that permits the patient to import these medicine in small quantity. Similar regulatory provision also exist in other countries. We assist patient in preparing legal documents for import and connecting them with authorized suppliers in USA and Europe to secure genuine products.

A generic drug is a drug defined as “a drug product that is comparable to a brand/reference listed drug product in dosage form, strength, quality and performance characteristics, and intended use”. There are Indian companies which manufacture and market these generic medicines after getting approval from Regulatory Authority of the country. These generic medicines contain the same active ingredients as the original formulation and are identical or within an acceptable bioequivalent range to the Innovator drug counterpart with respect to pharmacokinetic and pharmaco-dynamic properties. By extension, therefore, generics are considered identical in dose, strength, route of administration, safety, efficacy, and intended use. They are labeled with the name of the manufacturer and the adopted name (nonproprietary name) of the drug. When generic products become available, the market competition often leads to substantially lower prices and thereby make is affordable for large number of needy patients.

It usually takes 8-9 working days after dispatch to reach medicine at outside India locations. Additional delays may occur due to heavy load on postal services and customs.

We advise to transfer money only through Interbank Transfer Modalities;

  • Online Net-banking for within India transfer.
  • International Wire Transfer (SWIFT) from outside India.
  • Cash on Delivery within India.

Cash on Delivery (COD) option is only available if the medicine is purchased and delivered in India. Preferred locations within India for COD facilities are within Municipal limits of New Delhi & NCR, Mumbai, Bangalore, Kolkata, Chennai & Hyderabad

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